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PubMed COVID-19 Clinical Care

2161 - 2170 of 51504 results found

Harnessing noncanonical crRNAs to improve functionality of Cas12a orthologs

Date
Thursday, February 15, 2024 - 4:00 AM
Description
There is a broad diversity among Cas12a endonucleases that possess nucleic acid detection and gene-editing capabilities, but few are studied extensively. Here, we present an exhaustive investigation of 23 Cas12a orthologs, with a focus on their cis-

RNA therapeutics: Molecular mechanisms, and potential clinical translations

Date
Thursday, February 15, 2024 - 4:00 AM
Description
RNA therapies involve the utilization of natural and artificial RNA molecules to control the expression and function of cellular genes and proteins. Initializing from 1990s, RNA therapies now show the rapid growth in the development and application